OPAL Immunotherapy for AIDS

Grant number: 359281

Abstract

Chronic infections and cancers are major causes of global disease burden. Harnessing the immune system to combat these diseases has proven difficult and cumbersome to date. We invented a new technology to boost the ability of the immune system to fight chronic infections such as AIDS and Hepatitis C. This involves using someoneï¿1⁄2s own blood treated with sets of short proteins. We term this therapy Overlapping Peptide Pulsed Autologous CelLs (OPAL). This shows great promise in robust animal models. We now propose to refine this technique in animals in preparation for human clinical trials.

Related publications (2)

Low pre-infection levels and loss of central memory CD4 T cells may predict rapid progression in SIV-infected pigtail macaques

RD Mason, RD Rose, N Seddiki, AD Kelleher, SJ Kent

2008-11-10

CD4<sup>+</sup> T lymphocyte subsets are targeted to different degrees by SIV infection. We studied central memory, effector memor..

Control of viremia and prevention of AIDS following immunotherapy of SIV-infected macaques with peptide-pulsed blood

R De Rose, CS Fernandez, MZ Smith, CJ Batten, S Alcântara, V Peut, E Rollman, L Loh, RD Mason, K Wilson, MG Law, AJ Handley, SJ Kent

2008-05-01

Effective immunotherapies for HIV are needed. Drug therapies are life-long with significant toxicities. Dendritic-cell based immun..

University of Melbourne Researchers

Stephen Kent